1. Exploring promising spatial neurophysiological biomarkers of epileptic brain, and its mechanisms

a. Monsoor T, Zhang Y, Daida A, Oana S, Lu Q, Hussain SA, Fallah A, Sankar R, Staba RJ, Speier W, Roychowdhury V, and Nariai H. “Optimizing Detection and Deep Learning-based Classification of Pathological High-Frequency Oscillations in Epilepsy” medRxiv. 2023 Apr 17;2023.04.13.23288435. doi: 10.1101/2023.04.13.23288435. Preprint. PMID: 37131743

b. Zhang Y, Chung H, Ngo JP, Monsoor T, Hussain SA, Matsumoto JH, Walshaw PD, Fallah A, Sim MS, Asano E, Sankar R, Staba RJ, Engel J, Speier W, Roychowdhury V and Nariai H. "Characterizing physiological high-frequency oscillations using deep learning" J Neural Eng. 2022. (19)066027. DOI 10.1088/1741-2552/aca4fa. PMID: 36541546

c. Zhang Y, Lu Q, Monsoor T, Hussain SA, Qiao JX, Salamon N, Fallah A, Sim MS, Asano E, Sankar R, Staba RJ, Engel J, Speier W, Roychowdhury V, and Nariai H. “Refining epileptogenic high-frequency oscillations using deep learning: a reverse engineering approach.” Brain Commun. 2021 Nov 3;4(1):fcab267. doi: 10.1093/braincomms/fcab267. eCollection 2022. PMID: 35169696

d. Cepeda C, Levinson S, Nariai H, Yazon VW, Tran C, Barry J, Oikonomou K, Vinters HV, Fallah A, Mathern GW, Levine MS, and Wu JY. “Pathological High-Frequency Oscillations Associate with Increased Spontaneous GABA Synaptic Activity in Pediatric Epilepsy” Neurobiol Dis. 2020 Feb;134:104618. PMID: 31629890

2. Developing non-invasive neurophysiological biomarkers to monitor epilepsy severity, treatment response, and prognosticate clinical outcomes.

a. Lu M, Zhang Y, Diada A, Oana S, Rajaraman RR, Nariai H, Roychowdhury V, and Hussain SA. 2023. "Application of an EEG-based deep learning model to discriminate children with epileptic spasms from normal controls" medRxiv: 2023.06.30.23292096.

b. Mazumder R, Lagoro DK, Nariai H, Danieli A, Eliashiv D, Engel J Jr, Dalla Bernardina B, Kegele J, Lerche H, Sejvar J, Matuja W, Schmutzhard E, Bonanni P, De Polo G, Wagner T, Winkler AS. “Ictal Electroencephalographic Characteristics of Nodding Syndrome: A Comparative Case-Series from South Sudan, Tanzania, and Uganda” Ann Neurol. 2022 Apr 19. doi: 10.1002/ana.26377. PMID: 3543820

c. Miyakoshi M, Nariai H, Rajaraman RR, Bernardo D, Shrey DW, Lopour B, Sim MS, Staba RJ, and Hussain SA. “An automated pipeline for preprocessing scalp-recorded awake EEG data for phase-amplitude coupling analysis: application to infantile spasms.” Epilepsy Res. 2021 Dec;178:106809. doi: 10.1016/j.eplepsyres.2021.106809. Epub 2021 Nov 7. PMID: 34823159

d. Nariai H, Hussain SA, Bernardo D, Motoi H, Sonoda M, Kuroda N, Asano E, Nguyen J, Elashoff D, Sankar R, Bragin A, Staba RJ, Wu JY. Scalp EEG interictal high frequency oscillations as an objective biomarker of infantile spasms. Clin Neurophysiol. 2020 Sep 3;131(11):2527-2536. PMID: 32927206

3. Translational and clinical research on epileptic network and neuromodulation therapy for pediatric epilepsy.

a. Nagahama Y, Zervos T, Murata K, Holman L, Karsonovich T, Parker JJ, Chen JS, Phillips W, Fajardo M, Nariai H, Hussain S, Porter B, Grant GA, Ragheb J, Wang S, O’Neill BR, Alexander A, Bollo RJ, Fallah A. “Real-world preliminary experience with responsive neurostimulation in pediatric epilepsy: a multi-center retrospective observational study” Neurosurgery. 2021 Nov 18;89(6):997-1004. PMID: 34528103

b. Edmonds B, Miyakoshi M, Remore LG, Ahn S, Phillips W, Daida A, Salmon N, Bari A, Sankar R, Matsumoto JH, Fallah A, and Nariai H. “Characteristics of ictal thalamic EEG in pediatric-onset neocortical focal epilepsy” medRxiv. 2023 Jun29:2023.06.22.23291714. doi: 10.1101/2023.06.22.23291714. Preprint. PMID: 37425697

c. Ahn S, Edmonds B, Rajaraman R, Rao L, Hussain S, Lerner J, Sankar R, Matsumoto J, Fallah A, and Nariai H. “Bithalamic responsive neurostimulation for pediatric-onset medication-resistant epilepsy” Presented in AES 2022. Manuscript being submitted.